Elexacaftor,Tezacaftor,Ivacaftor

This medication is a therapeutic combination containing three drugs that work together to treat specific types of cystic fibrosis (CF). Cystic fibrosis is a genetic disorder that affects the lungs, digestive system, and other organs in the body.

How Does This Medication Work?

• Elexacaftor and Tezacaftor: These two drugs are "protein correctors." They help repair the defective protein known as Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In cystic fibrosis patients, this protein is defective, preventing it from reaching the cell surface in sufficient amounts. Elexacaftor and Tezacaftor increase the amount of functional protein that reaches the cell surface.
• Ivacaftor: This drug is a "protein potentiator." It improves the function of the CFTR protein once it reaches the cell surface. This improvement helps reduce the buildup of thick mucus in the lungs and enhances other symptoms of cystic fibrosis.

In Simple Terms:

These three medications work together to repair the defective CFTR protein and improve its function, helping to relieve the symptoms of cystic fibrosis.